Blar i NIBIO Brage på forfatter "Bock, Ralph"
-
Hepatitis C virus E2 envelope glycoprotein produced in Nicotiana benthamiana triggers humoral response with virus-neutralizing activity in vaccinated mice
Dobrica, Mihaela-Olivia; van Eerde, André; Tucureanu, Catalin; Onu, Adrian; Paruch, Lisa; Caras, Iuliana; Vlase, Ene; Steen, Hege; Haugslien, Sissel; Alonzi, Dominic; Zitzmann, Nicole; Bock, Ralph; Dubuisson, Jean; Popescu, Costin-Ioan; Stavaru, Crina; Clarke, Jihong Liu; Branza-Nichita, Norica (Peer reviewed; Journal article, 2021-05-18)Chronic infection with hepatitis C virus (HCV) remains a leading cause of liver-related pathologies and a global health problem, currently affecting more than 71 million people worldwide. The development of a prophylactic ... -
In-depth characterization of Trichoderma reesei cellobiohydrolase TrCel7A produced in Nicotiana benthamiana reveals limitations of cellulase production in plants by host-specific post-translational modifications
van Eerde, André; Varnai, Aniko; Jameson, John-Kristian; Paruch, Lisa; Moen, Anders; Anonsen, Jan Haug; Chylenski, Piotr; Steen, Hege; Heldal, Inger; Bock, Ralph; Eijsink, Vincent; Clarke, Jihong Liu (Journal article; Peer reviewed, 2019)Sustainable production of biofuels from lignocellulose feedstocks depends on cheap enzymes for degradation of such biomass. Plants offer a safe and cost‐effective production platform for biopharmaceuticals, vaccines and ... -
Lettuce-produced hepatitis C virus E1E2 heterodimer triggers immune responses in mice and antibody production after oral vaccination
Clarke, Jihong; Paruch, Lisa; Dobrica, Mihaela-Olivia; Caras, Iuliana; Tucureanu, Catalin; Onu, Adrian; Ciulean, Sonya; Stavaru, Crina; van Eerde, André; Wang, Yanliang; Steen, Hege; Haugslien, Sissel; Petrareanu, Catalina; Lazar, Catalin; Popescu, Costin-loan; Bock, Ralph; Dubuisson, Jean; Branza-Nichita, Norica (Journal article; Peer reviewed, 2017)The hepatitis C virus (HCV) is a major etiologic agent for severe liver diseases ( e.g . cirrhosis, fibrosis and hepatocellular carcinoma). Approximately 140 million people have chronic HCV infections and about 500 000 die ... -
Plant-made vaccines against viral diseases in humans and farm animals
Su, Hang; van Erde, André; Rimstad, Espen; Bock, Ralph; Branza-Nichita, Norica; Yakovlev, Igor; Liu Clarke, Jihong (Peer reviewed; Journal article, 2023-03-28)Plants provide not only food and feed, but also herbal medicines and various raw materials for industry. Moreover, plants can be green factories producing high value bioproducts such as biopharmaceuticals and vaccines. ... -
Production of tetravalent dengue virus envelope protein domain III based antigens in lettuce chloroplasts and immunologic analysis for future oral vaccine development
van Eerde, André; Gottschamel, Johanna; Bock, Ralph; Hansen, Kristine Eraker Aasland; Munangandu, Hetron Mweemba; Daniell, Henry; Clarke, Jihong Liu (Journal article; Peer reviewed, 2018-12-22)Dengue fever is a mosquito (Aedes aegypti) ‐transmitted viral disease that is endemic in more than 125 countries around the world. There are four serotypes of the dengue virus (DENV 1‐4) and a safe and effective dengue ...